I tried them but in fairness not the full recommended amount. I saw no measurable drop in Nitrates but again my very old system/substrate/rock has proven to be very resistant to change. I started with them in a reactor with an airline plumbed in. When I was not seeing any results, I switched to the recommended "bomb" in one of my overflow boxes. Where I didn't get the nitrate reduction I was hoping for, merely some stabilization, I still like the theory behind them and one worthwhile bonus is that the overflow box that the bomb is in is teeming with a huge colony of Mysid shrimp. the bacteria on the cubes seems to supply a good food source for their fry.
They may be more effective in a more "normal" environment and they didn't cause the Cyano blooms that I have gotten with bio-pellets, I believe due to the fact that they broadcast less carbon into the general system, rather letting the bacteria propagate in the pores of the cubes. I would have loved to try again at the full recommended dosage but their biggest drawback is their price when dealing with a very large system.