I have seen people that had a really big outbreak of these in the tank and after they dosed it killed the tank. It really depends on how many you have, what species they are as they very in toxicness and what corals and other life you have in the tank. All tanks react differently to the toxins and just because one species is fine doesn't mean the next one is. My recommendation's are based on being cautious and my experience with these for I have seen them many times over my years in this hobby and I have witnessed the sometimes drastic effects they have had in peoples tanks. People can do a full dose if they want but if you have the red flatworm they are toxic and can wipe out a tank if the density is great enough. Remember if you see some there are lots you can't see.
I like the manual removal approach if at all possible as it is the cheapest and one of the safest way of controlling them. If the bio load in the tank allows it and the tank is big enough to safely add a fish some wrasse will control these like the Melanurus wrasse or green wrasse.
Check out this link for removal tips.
http://www.melevsreef.com/node/651